Dynamic modeling of bone metastasis, microenvironment and therapy: Integrating parathyroid hormone (PTH) effect, anti-resorptive and anti-cancer therapy
详细信息 查看全文
- 作者：Rui Moura Coelhoa ; rui.coelho@tecnico.ulisboa.pt" class="auth_mail" title="E-mail the corresponding author ; Joã ; o Miranda Lemosb ; jlml@inesc-id.pt" class="auth_mail" title="E-mail the corresponding author ; Irina Alhoc ; ialho@medicina.ulisboa.pt" class="auth_mail" title="E-mail the corresponding author ; Duarte Valé ; rioa ; duarte.valerio@tecnico.ulisboa.pt" class="auth_mail" title="E-mail the corresponding author ; Arlindo R Ferreirad ; c ; ajrsferreira@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Luí ; s Costad ; c ; luiscosta.oncology@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Susana Vingaa ; susanavinga@tecnico.ulisboa.pt" class="auth_mail" title="E-mail the corresponding author
- 关键词：Bone remodeling ; Bone metastasis ; Systems biomedicine
- 刊名：Journal of Theoretical Biology
- 出版年：2016
- 出版时间：21 February 2016
- 年：2016
- 卷：391
- 期：Complete
- 页码：1-12
- 全文大小：1218 K
文摘
- class="listitem" id="list_li0005">
- class="label">•
A model for bone remodeling that includes PTH is proposed.
- class="label">•
PTHrP is included to account for the vicious cycle of bone metastases.
- class="label">•
PK/PD of bisphosphonates, denosumab and chemotherapy are included as treatment.
- class="label">•
Model simulations illustrate how anti-cancer and anti-resorptive therapies on bone metastases can reduce tumor burden and restore bone health.