Deciphering the Innate Lymphoid Cell Transcriptional Program
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- 作者：Cyril Seillet1 ; 2 ; seillet@wehi.edu.au" class="auth_mail" title="E-mail the corresponding author ; Lisa A. Mielke1 ; 2 ; Daniela B. Amann-Zalcenstein1 ; 2 ; Shian Su1 ; 2 ; Jerry Gao1 ; 2 ; Francisca F. Almeida1 ; 2 ; Wei Shi1 ; 2 ; 3 ; Matthew E. Ritchie1 ; 2 ; Shalin H. Naik1 ; 2 ; Nicholas D. Huntington1 ; 2 ; Sebastian Carotta1 ; 4 ; sebastian.carotta@boehringer-ingelheim.com" class="auth_mail" title="E-mail the corresponding author ; Gabrielle T. Belz1 ; 2 ; 5 ; belz@wehi.edu.au" class="auth_mail" title="E-mail the corresponding author
- 关键词：innate lymphoid cells ; development ; immunity ; transcription factors ; innate
- 刊名：Cell Reports
- 出版年：2016
- 出版时间：4 October 2016
- 年：2016
- 卷：17
- 期：2
- 页码：436-447
- 全文大小：7858 K
文摘
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ILCp transcriptomics define the blueprint for hierarchical ILC development
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PD-1 identifies the PLZF-expressing ILC precursor in the bone marrow
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Transient NFIL3 expression prior to ID2 expression is required for ILC development
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ID2 and TCF-1 are required to extinguish stem cell and B and T cell gene programs