Reduced occurrence of ventilator-associated pneumonia after cardiac surgery using preoperative 0.2% chlorhexidine oral rinse: results from a single-centre single-blinded randomized trial
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- 作者：Y.J. Lin ; fjxhlyj@163.com" class="auth_mail" title="E-mail the corresponding author ; L. Xu ; X.Z. Huang ; F. Jiang ; S.L. Li ; F. Lin ; Q.Y. Ye ; M.L. Chen ; J.L. Lin
- 关键词：Cardiac surgery ; Chlorhexidine ; Prophylaxis ; Ventilator-associated pneumonia
- 刊名：Journal of Hospital Infection
- 出版年：2015
- 出版时间：December 2015
- 年：2015
- 卷：91
- 期：4
- 页码：362-366
- 全文大小：266 K
文摘
Since mechanical ventilation after cardiac surgery increases the risk of ventilator-associated pneumonia (VAP), we conducted a prospective randomized controlled trial to investigate the effect of preoperative 0.2% chlorhexidine on postoperative VAP. Ninety-four patients scheduled for heart surgery were randomized to a chlorhexidine group (N = 47) or control (saline) group (N = 47). On the day before surgery, patients gargled three times with 0.2% chlorhexidine or saline 30 min after each meal and 5 min after teeth brushing at bedtime. VAP occurred in 8.5% of the chlorhexidine group and in 23.4% of the controls. Preoperative chlorhexidine mouthwash reduced the incidence of postoperative VAP significantly.