Mutations in genes encoding for mitochondrial or lysosomal proteins lead to severe diseases.

Mitochondrial malfunction triggers increase in number of autophagosomes.

Mitochondrial stress leads to lysosomal dysfunction and accumulation of autophagy intermediates.

Mitochondrial stress triggers lysosomal biogenesis in dividing cells.

Lysosomal defects trigger mitochondrial perturbations.

Mitochondria and lysosomes show interdependence, as dysfunction of one results in perturbation of the other.