ALKBH1-Mediated tRNA Demethylation Regulates Translation
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- 作者：Fange Liu1 ; 2 ; Wesley Clark3 ; Guanzheng Luo1 ; 2 ; Xiaoyun Wang3 ; Ye Fu1 ; 2 ; Jiangbo Wei1 ; 2 ; Xiao Wang1 ; 2 ; Ziyang Hao1 ; 2 ; Qing Dai1 ; 2 ; Guanqun Zheng3 ; Honghui Ma1 ; 2 ; Dali Han1 ; 2 ; Molly Evans3 ; Arne Klungland4 ; 5 ; Tao Pan3 ; taopan@uchicago.edu" class="auth_mail" title="E-mail the corresponding author ; Chuan He1 ; 2 ; 3 ; 6 ; chuanhe@uchicago.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：ALKBH1 ; tRNA methylation ; tRNA demethylation ; tRNA demethylase ; N1-methyladenosine (m1A) ; translation initiation ; translation elongation ; codon usage ; translation regulation ; dynamic tRNA modification
- 刊名：Cell
- 出版年：2016
- 出版时间：20 October 2016
- 年：2016
- 卷：167
- 期：3
- 页码：816-828.e16
- 全文大小：4085 K
文摘
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ALKBH1 catalyzes the demethylation of m1A in tRNA
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The m1A demethylation affects the tRNAiMet level and translation initiation
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The ALKBH1-mediated tRNA demethylation attenuates translation elongation
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Reversible tRNA methylation dynamically regulates translation