Independent origins of loss-of-function mutations conferring oxamniquine resistance in a Brazilian schistosome population
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- 作者：Fré ; dé ; ric D. Chevaliera ; fcheval@txbiomed.org" class="auth_mail" title="E-mail the corresponding author ; Winka Le Clec&rsquo ; ha ; Nina Enga ; Anastasia R. Rugelb ; c ; Rafael Ramiro de Assisd ; Guilherme Oliveirad ; e ; Stephen P. Hollowayb ; c ; Xiaohang Caob ; c ; P. John Hartb ; c ; f ; Philip T. LoVerdeb ; c ; Timothy J.C. Andersona ; tanderso@txbiomed.org" class="auth_mail" title="E-mail the corresponding author
- 关键词：Schistosoma mansoni ; Oxamniquine resistance ; Sulfotransferase ; Loss-of-function ; Biochemical assay ; Soft selective event
- 刊名：International Journal for Parasitology
- 出版年：2016
- 出版时间：June 2016
- 年：2016
- 卷：46
- 期：7
- 页码：417-424
- 全文大小：666 K
文摘
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We surveyed allelic variation in a schistosome drug resistance gene.
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There were four independent origins of alleles encoding loss-of-function proteins.
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Resistance mutations are at a very low frequency (<0.0080).
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Loss-of-function mutations were tested using an in vitro oxamniquine activation assay.