Localization of dipeptidyl peptidase-4 (CD26) to human pancreatic ducts and islet alpha cells
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- 作者：Petra Augsteina ; b ; paugstein@diabetes-karlsburg.de" class="auth_mail" title="E-mail the corresponding author ; Gaetano Nasellia ; naselli@wehi.edu.au" class="auth_mail" title="E-mail the corresponding author ; Thomas Loudovarisc ; tloudovaris@svi.edu.au" class="auth_mail" title="E-mail the corresponding author ; Wayne J. Hawthorned ; wayne.hawthorne@sydney.edu.au" class="auth_mail" title="E-mail the corresponding author ; Peter Campbellc ; Esther Bandala-Sancheza ; bandala@wehi.edu.au" class="auth_mail" title="E-mail the corresponding author ; Kelly Rogersa ; rogers@wehi.edu.au" class="auth_mail" title="E-mail the corresponding author ; Peter Heinkeb ; heinke@diabetes-karlsburg.de" class="auth_mail" title="E-mail the corresponding author ; Helen E. Thomasc ; hthomas@svi.edu.au" class="auth_mail" title="E-mail the corresponding author ; Thomas W. Kayc ; tkay@svi.edu.au" class="auth_mail" title="E-mail the corresponding author ; Leonard C. Harrisona ; harrison@wehi.edu.au" class="auth_mail" title="E-mail the corresponding author
- 关键词：APAAP ; alkaline phosphatase-anti-alkaline phosphatase ; DPP-4 ; dipeptidyl peptidase IV ; FCS ; fetal calf serum ; GAD Ab ; glutamic acid decarboxylase 65 antibody ; GIP ; gastric inhibitory peptide ; GLP-1 ; glucagon-like peptide 1 ; SSC ; side scatter
- 刊名：Diabetes Research and Clinical Practice
- 出版年：2015
- 出版时间：December 2015
- 年：2015
- 卷：110
- 期：3
- 页码：291-300
- 全文大小：3683 K
文摘
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In the human pancreas, DPP-4 expression is localized to duct and alpha cells.
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In donors with type 1 diabetes, the majority of islet cells are DPP-4-positive.
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In donors without diabetes, DPP-4 and proinsulin have a distinct expression.
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In duct-enriched samples, the majority of DPP-4-positive cells express CD133.