Gonadal soma-derived factor (gsdf), a TGF-beta superfamily gene, induces testis differentiation in the teleost fish Oreochromis niloticus
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- 作者：Hiroyo Kanekoa ; b ; hkaneko@nibb.ac.jp" class="auth_mail" title="E-mail the corresponding author ; Shigeho Ijiria ; b ; c ; ijiri@fish.hokudai.ac.jp" class="auth_mail" title="E-mail the corresponding author ; Tohru Kobayashia ; d ; tohruk@u-shizuoka-ken.ac.jp" class="auth_mail" title="E-mail the corresponding author ; Hikari Izumic ; h-izumi@eis.hokudai.ac.jp" class="auth_mail" title="E-mail the corresponding author ; Yuki Kuramochic ; yuki.kuramochi15@gmail.com" class="auth_mail" title="E-mail the corresponding author ; De-Shou Wanga ; b ; 1 ; wdeshou@swu.edu.cn" class="auth_mail" title="E-mail the corresponding author ; Shouta Mizunoc ; mizunoshouta1003@frontier.hokudai.ac.jp" class="auth_mail" title="E-mail the corresponding author ; Yoshitaka Nagahamaa ; b ; e ; nagahama.yoshitaka.mh@ehime-u.ac.jp" class="auth_mail" title="E-mail the corresponding author
- 关键词：gsdf ; Sex differentiation ; Sex determination ; dmrt1 ; Nile tilapia
- 刊名：Molecular and Cellular Endocrinology
- 出版年：2015
- 出版时间：5 November 2015
- 年：2015
- 卷：415
- 期：Complete
- 页码：87-99
- 全文大小：4165 K
文摘
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Gsdf is expressed predominantly in XY gonads in the Nile tilapia.
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Gsdf expression pattern shows sexual dimorphism before morphological differentiation.
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Gsdf expression is the earliest gene expression detected in testis differentiation.
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Overexpression of gsdf is sufficient to induce testis differentiation in XX tilapia.