An intracellularly expressed Nsp9-specific nanobody in MARC-145 cells inhibits porcine reproductive and respiratory syndrome virus replication
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- 作者：Hongliang Liua ; b ; 1 ; liuhongliang55@126.com" class="auth_mail" title="E-mail the corresponding author ; Yan Wanga ; b ; 1 ; wangyanfushi@163.com" class="auth_mail" title="E-mail the corresponding author ; Hong Duana ; b ; duanhong910924@sina.com" class="auth_mail" title="E-mail the corresponding author ; Angke Zhanga ; b ; zhangangke1112@126.com" class="auth_mail" title="E-mail the corresponding author ; Chao Lianga ; b ; chaonvlc@163.com" class="auth_mail" title="E-mail the corresponding author ; Jiming Gaoa ; b ; jimingao2006@163.com" class="auth_mail" title="E-mail the corresponding author ; Chong Zhanga ; b ; leofighting@163.com" class="auth_mail" title="E-mail the corresponding author ; Baicheng Huanga ; b ; hbch228@163.com" class="auth_mail" title="E-mail the corresponding author ; Qiongyi Lia ; b ; jean_lqy@sina.com" class="auth_mail" title="E-mail the corresponding author ; Na Lia ; b ; lina330077@163.com" class="auth_mail" title="E-mail the corresponding author ; Shuqi Xiaoa ; b ; xiaoshuqi@nwsuaf.edu.cn" class="auth_mail" title="E-mail the corresponding author ; En-Min Zhoua ; b ; zhouem@nwsuaf.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：Intrabody ; Nanobody ; Nsp9 ; PRRSV ; VHH
- 刊名：Veterinary Microbiology
- 出版年：2015
- 出版时间：31 December 2015
- 年：2015
- 卷：181
- 期：3-4
- 页码：252-260
- 全文大小：1800 K
文摘
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PRRSV Nsp9-specific nanobodies were isolated from a camel VHH library.
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Intracellurly expressed Nsp9-sepcific nanobody (Nb6) in MARC-145 cells inhibits PRRSV replication.
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Nb6 expressed in MARC-145 Nb6 inhibits replication of multiple strains of PRRSV.