Puberty is highly sensitive to metabolic modulation and disturbed by child obesity.
Altered puberty is linked to adverse metabolic health outcomes via unclear mechanisms.
The POMC product, α-MSH, transmit leptin-mediated metabolic regulation of puberty.
A novel α-MSH→kisspeptin→GnRH signaling pathway is involved in the control of puberty
This pathway is important for the metabolic (and pharmacologic) control of puberty.