Inhalation therapy with M1 inhibits experimental melanoma development and metastases in mice
详细信息 查看全文
- 作者：Lucas Ferrari de Andrade1 ; Brian Mozeleski2 ; brian.mozeleski@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Aline Raquell Leck1 ; Gustavo Rossi1 ; Cleber Rafael Vieira da Costa1 ; Fernando de Souza Fonseca Guimarã ; es3 ; fernando.guimaraes@qimrberghofer.edu.au" class="auth_mail" title="E-mail the corresponding author ; Rafael Zotz4 ; rafael.zotz@pucpr.br" class="auth_mail" title="E-mail the corresponding author ; Katia Fialho do Nascimento1 ; Carolina Camargo de Oliveira1 ; Dorly de Freitas Buchi1 ; Edvaldo da Silva Trindade1 ; labbiocel@ufpr.br" class="auth_mail" title="E-mail the corresponding author
- 关键词：Melanoma ; Homeopathy ; M1 ; Angiotensin II receptor ; Angiogenesis ; Tumor growth
- 刊名：Homeopathy
- 出版年：2016
- 出版时间：February 2016
- 年：2016
- 卷：105
- 期：1
- 页码：109-118
- 全文大小：3105 K
文摘
- class="listitem" id="list_ulist0010">
- class="label">•
This is the first description of M1's anti-melanoma properties.
- class="label">•
We demonstrate a mechanism of action by multi-parameter analyses.
- class="label">•
We show therapeutic potential of AT1R inhibition on myeloid-derived suppressor cells as a novel therapeutic target.
- class="label">•
We offer new insights into the importance of blocking initial pathways of tumor metastases.