Mast cells in rheumatic disease

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• 作者：Jolien Suurmond^a ; ¹ ; ² ; ^{jsuurmond@nshs.edu" class="auth_mail" title="E-mail the corresponding author} ; Danië ; l van der Velden^a ; ^b ; ¹ ; ^{d.van_der_velden@lumc.nl" class="auth_mail" title="E-mail the corresponding author} ; Johan Kuiper^b ; ^{j.kuiper@lacdr.leidenuniv.nl" class="auth_mail" title="E-mail the corresponding author} ; Ilze Bot^b ; ^{i.bot@lacdr.leidenuniv.nl" class="auth_mail" title="E-mail the corresponding author} ; René ; E.M. Toes^a ; ^{r.e.m.toes@lumc.nl" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Cromolyn sodium salt (PubChem CID ; 16219066) ; Cromoglicate lisetil (PubChem CID ; 196639) ; Histamine (PubChem CID ; 774) ; Salbutamol (PubChem CID ; 2083) ; Leukotriene B4 (PubChem CID ; 5280492) ; Interleukin-8 (PubChem CID ; 44357137)
• 刊名：European Journal of Pharmacology
• 出版年：2016
• 出版时间：5 May 2016
• 年：2016
• 卷：778
• 期：Complete
• 页码：116-124
• 全文大小：834 K

文摘

Rheumatoid Arthritis is a chronic autoimmune disease with a complex disease pathogenesis leading to inflammation and destruction of synovial tissue in the joint. Several molecules lead to activation of immune pathways, including autoantibodies, Toll-Like Receptor ligands and cytokines. These pathways can cooperate to create the pro-inflammatory environment that results in tissue destruction. Each of these pathways can activate mast cells, inducing the release of a variety of inflammatory mediators, and in combination can markedly enhance mast cell responses. Mast cell-derived cytokines, chemokines, and proteases have the potential to induce recruitment of other leukocytes able to evoke tissue remodeling or destruction. Likewise, mast cells can secrete a plethora of factors that can contribute to tissue remodeling and fibroblast activation. Although the functional role of mast cells in arthritis pathogenesis in mice is not yet elucidated, the increased numbers of mast cells and mast cell-specific mediators in synovial tissue of rheumatoid arthritis patients suggest that mast cell activation in rheumatoid arthritis may contribute to its pathogenesis.