A Force-Induced Directional Switch of a Molecular Motor Enables Parallel Microtubule Bundle Formation
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- 作者：Maxim I. Molodtsov1 ; 2 ; 3 ; 6 ; Christine Mieck1 ; 6 ; Jeroen Dobbelaere2 ; Alexander Dammermann2 ; Stefan Westermann1 ; 4 ; stefan.westermann@uni-due.de" class="auth_mail" title="E-mail the corresponding author ; Alipasha Vaziri1 ; 2 ; 3 ; 5 ; 7 ; vaziri@rockefeller.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：Parallel microtubules ; kinesin-14 ; Cik1-Kar3 ; EB1 ; polarization ; plus-end guiding ; microtubule polymerization ; directional switch
- 刊名：Cell
- 出版年：2016
- 出版时间：6 October 2016
- 年：2016
- 卷：167
- 期：2
- 页码：539-552.e14
- 全文大小：6473 K
文摘
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EB1 and kinesin-14 guide growth of parallel microtubules from a common MTOC
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Kinesin-14 Cik1-Kar3 reverses direction under a low external force
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Cik1-Kar3 moves by exploiting a nucleotide-dependent asymmetric binding potential
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Cdk1-dependent tail phosphorylation renders the process of bundle formation reversible