Impedimetric real-time monitoring of neural pluripotent stem cell differentiation process on microelectrode arrays
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- 作者：Diana Seidela ; Janine Obendorfa ; Beate Englicha ; Heinz-Georg Jahnkea ; Vesselina Semkovae ; Simone Hauptd ; e ; Mathilde Girardb ; Marc Peschanskic ; Oliver Brü ; stled ; e ; Andrea A. Robitzkia ; andrea.robitzki@bbz.uni-leipzig.de" class="auth_mail" title="E-mail the corresponding author
- 关键词：Label-free neuronal differentiation monitoring ; Impedance spectroscopy ; Neuronal stem cells ; Microelectrode array ; Equivalent circuit modeling
- 刊名：Biosensors and Bioelectronics
- 出版年：2016
- 出版时间：15 December 2016
- 年：2016
- 卷：86
- 期：Complete
- 页码：277-286
- 全文大小：6398 K
文摘
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Impedance spectroscopy can be used to specifically monitor neuronal differentiation.
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Neural stem cell differentiation to neurons was successfully displayed.
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Identified impedimetric parameters were validated by neuronal marker analysis.
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The observed effects were explained by applying an equivalent circuit model.
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Our system can be used for the screening of differentiation acceleration compounds.