Visualization of G-quadruplexes in gel and in live cells by a near-infrared fluorescent probe
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- 作者：Fan Wua ; 1Author Vitae ; Chaoxing Liua ; 1Author Vitae ; Yuqi ChenaAuthor Vitae ; Shixi YangaAuthor Vitae ; Jiahui XuaAuthor Vitae ; Rong HuangcAuthor Vitae ; Xiang WangaAuthor Vitae ; Manjia LiaAuthor Vitae ; Wenting LiuaAuthor Vitae ; Wuxiang Maob ; maowuxiang@163.com" class="auth_mail" title="E-mail the corresponding authorAuthor Vitae ; Xiang Zhoua ; xzhou@whu.edu.cn" class="auth_mail" title="E-mail the corresponding authorAuthor Vitae
- 关键词：Fluorescent probe ; G-quadruplex ; Direct visualization ; Cell imaging
- 刊名：Sensors & Actuators: B. Chemical
- 出版年：2016
- 出版时间：29 November 2016
- 年：2016
- 卷：236
- 期：Complete
- 页码：268-275
- 全文大小：1842 K
文摘
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We have successfully synthesized a near-infrared fluorescent probe, named PDP-Cy5, realizing visualization of DNA and RNA G-quadruplexes.
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PDP-Cy5 had excellent selectivity for G-quadruplexes, eliminating interference of other structures of nucleic acids.
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PDP-Cy5 also performed surprising ability to stabilize G-quadruplexes.