Metal complexes of anthranilic acid derivatives: A new class of non-competitive α-glucosidase inhibitors

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• 作者：Jing-Wei Zheng ; ^{zhengjnw@mail2.sysu.edu.cn" class="auth_mail" title="E-mail the corresponding author} ; Lin Ma
• 关键词：α-Glucosidase ; Anthranilic acid derivatives ; Metal complexes ; Noncompetitive inhibitors
• 刊名：Chinese Chemical Letters
• 出版年：2016
• 出版时间：May 2016
• 年：2016
• 卷：27
• 期：5
• 页码：627-630
• 全文大小：339 K

文摘

Metal complexes of anthranilic acid derivatives that constitute a novel class of non-sugar-type α-glucosidase inhibitors were synthesized and assessed in vitro for inhibitory activity. All of the Ag(I) complexes (class="boldFont">9–class="boldFont">16) inhibited α-glucosidase at the nanomolar scale, while 3,5-dichloroanthranilic acid silver(I) (class="boldFont">9) was the most potent (IC₅₀ = 3.21 nmol/L). Analysis of the kinetics of enzyme inhibition indicated that the mechanism of the newly prepared silver complexes was noncompetitive. The structure-activity relationships were also analyzed, and they are discussed in this report.