Developmental Origin of Oligodendrocyte Lineage Cells Determines Response to Demyelination and Susceptibility to Age-Associated Functional Decline
详细信息 查看全文
- 作者：Abbe H. Crawford1 ; Richa B. Tripathi2 ; William D. Richardson2 ; 3 ; w.richardson@ucl.ac.uk" class="auth_mail" title="E-mail the corresponding author ; Robin J.M. Franklin1 ; 3 ; rjf1000@cam.ac.uk" class="auth_mail" title="E-mail the corresponding author
- 关键词：myelin ; oligodendrocyte ; glial diversity ; remyelination ; oligodendrocyte progenitor
- 刊名：Cell Reports
- 出版年：2016
- 出版时间：26 April 2016
- 年：2016
- 卷：15
- 期：4
- 页码：761-773
- 全文大小：4889 K
文摘
- •
Oligodendrocyte progenitors arise from distinct ventral and dorsal domains
- •
Dorsal progenitors exhibit enhanced recruitment and differentiation in remyelination
- •
Dorsal progenitors become less able to differentiate with aging