Prion diseases: New considerations
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- 作者：Á ; dá ; m Annus ; MDa ; annus.adam@med.u-szeged.hu" class="auth_mail" title="E-mail the corresponding author ; Anett Csá ; ti ; MD PhDa ; anett.csati@med.u-szeged.hu" class="auth_mail" title="E-mail the corresponding author ; Lá ; szló ; Vé ; csei ; MD PhD DSca ; b ; laszlo.vecsei@med.u-szeged.hu" class="auth_mail" title="E-mail the corresponding author ; vecsei.laszlo@med.u-szeged.hu" class="auth_mail" title="E-mail the corresponding author (Member of the Hungarian Academy of Sciences Head of the Department of Neurology)
- 关键词：α-syn ; α-synuclein ; Aβ ; β-amyloid ; AD ; Alzheimer&rsquo ; s disease ; ADAMs ; a disintegrin and metalloproteinases ; ALS ; amyotrophic lateral sclerosis ; BSE ; bovine spongiform encephalopathy ; CJD ; Creutzfeldt-Jakob disease ; CNS ; central nervous system ; CSF ; cerebrospinal fluid ; EEG ; electroencephalogram ; gCJD ; genetic Creutzfeldt-Jakob disease ; GPI anchor ; glycophosphoinositol anchor ; HD ; Huntington&rsquo ; s disease ; iCJD ; iatrogenic CJD ; KYNA ; kynurenic acid ; MRI ; magnetic resonance imaging ; NDs ; neur
- 刊名：Clinical Neurology and Neurosurgery
- 出版年：2016
- 出版时间：November 2016
- 年：2016
- 卷：150
- 期：Complete
- 页码：125-132
- 全文大小：1072 K
文摘
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Prionopathies are characterised by the accumulation of abnormal misfolded proteins.
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Neurodegenerative diseases, e.g. Parkinson’s disease, share prion-like attributes.
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Prion protein was detected in the nasal mucosa and urine of patients with Creutzfeldt-Jakob disease.
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These findings raise new health care concerns and warrant new considerations.