CSF tau correlates with the degree of cortical involvement in E200K familial Creutzfeldt-Jakob disease
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- 作者：Dr. Oren S. Cohen ; MDa ; b ; coheno@asaf.health.gov.il" class="auth_mail" title="E-mail the corresponding author ; orenc@post.tau.ac.il" class="auth_mail" title="E-mail the corresponding author ; sarioren@hotmail.com" class="auth_mail" title="E-mail the corresponding author ; Joab Chapman ; MDb ; c ; d ; Amos D. Korczyn ; MD ; MScb ; Oliver L. Siaw ; BSce ; Naama Warman-Alaluf ; MScc ; Zeev Nitsan ; MDf ; Shmuel Appel ; MDf ; Esther Kahana ; MDf ; Hanna Rosenmann ; PhDg ; Chen Hoffmann ; MDb ; h
- 关键词：Creutzfeldt-Jakob disease ; E200K mutation ; Tau protein ; MRI ; Disease severity
- 刊名：Neuroscience Letters
- 出版年：2016
- 出版时间：10 November 2016
- 年：2016
- 卷：634
- 期：Complete
- 页码：76-78
- 全文大小：338 K
文摘
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CSF tau was previously found to correlate with disease severity and cognitive status in familial Creutzfeldt-Jakob disease (fCJD) patients.
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In the present study A significant correlation (r = 0.617 p < 0.0001) was found between CSF tau levels and the extent of cortical involvement.
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This correlation suggest that tau can be used as a biomarker reflecting the extent of neuronal damage in patients with fCJD.