Fatigue favors in vitro Th1 and Th17-like cell expansion and reduces corticoid sensitivity in MS patients

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• 作者：Hé ; lcio Alvarenga-Filho^a ; ¹ ; Marisa Salles^b ; ¹ ; Joana Hygino^b ; Thais B. Ferreira^b ; Priscila M. Sacramento^b ; Clarice Monteiro^b ; Claudia Cristina F. Vasconcelos^b ; Regina Maria Papais Alvarenga^a ; Cleonice A.M. Bento^a ; ^b ; ^{cbento@unirio.br}
• 关键词：Multiple sclerosis ; Cytokines ; Fatigue ; Corticoid
• 刊名：Journal of Neuroimmunology
• 出版年：2017
• 出版时间：15 February 2017
• 年：2017
• 卷：303
• 期：Complete
• 页码：81-89
• 全文大小：1485 K
• 卷排序：303

文摘

Higher levels of Th17-related cytokines were observed in MS patients with fatigue. The in vivo IL-6, TNF-α and IL-17 was associated with fatigue severity in MS patients. HC was less efficient in inhibiting cytokine production in MS patients with fatigue.