Effect of COMT genotype on aggressive behaviour in a community cohort of schizophrenic patients

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• 作者：Sarah Tosato^a ; ^{sarah.tosato@univr.it"" rel=""nofollow} ; Chiara Bonetto^a ; Marta Di Forti^c ; David Collier^d ; Doriana Cristofalo^a ; Mariaelena Bertani^a ; Martina Zanoni^a ; Giovanna Marrella^a ; Lorenza Lazzarotto^a ; Antonio Lasalvia^a ; Marzia De Gironcoli^b ; Michele Tansella^a ; Paola Dazzan^c ; Robin Murray^c ; Mirella Ruggeri^a
• 关键词：Aggression ; COMT ; Schizophrenia ; Outcome
• 刊名：Neuroscience Letters
• 出版年：2011
• 出版时间：9 May 2011
• 年：2011
• 卷：495
• 期：1
• 页码：17-21
• 全文大小：147 K

文摘

Although the etiology of aggression is multifactorial, many studies have associated the Val158Met polymorphism of the COMT with aggression in schizophrenia. This study tests the hypothesis that Met/Met patients display more episodes of aggression and violent behaviour than Val/Val patients in a 6 year follow-up cohort of subjects with schizophrenia in contact with the South-Verona Community-based Mental Health Service. Out of the 141 subjects with an ICD-10 SCAN-confirmed diagnosis of schizophrenia, 115 completed both baseline and follow-up assessments (81.6 % of the baseline cohort). Of these, 80 subjects (70 % ) were genotyped and rated for aggression using the Overt Aggression Scale.

Met/Met homozygous patients had higher aggressive behaviour compared to Val/Val homozygous subjects. Antipsychotic dosage, alcohol and drug abuse were taken into account as confounders. The Met/Met genotype of COMT may have an effect on aggressive behaviour in schizophrenia because norepinephrine is less effectively inactivated.