Sodium fluoride as an efficient catalyst for the synthesis of 2,4-disubstituted-1,3-thiazoles and selenazoles at ambient temperature

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• 作者：Janardhan Banothu ; Krishnaiah Vaarla ; Rajitha Bavantula ; Peter A. Crooks
• 关键词：Sodium fluoride ; 1 ; 3-Thiazoles ; Selenazoles ; Aqueous methanol ; Ambient temperature
• 刊名：Chinese Chemical Letters
• 出版年：January, 2014
• 年：2014
• 卷：25
• 期：1
• 页码：172-175
• 全文大小：469 K

文摘

Sodium fluoride was found to be a simple, mild and efficient catalyst for the synthesis of 2,4-disubstituted 1,3-thiazoles and selenazoles utilizing phenacyl bromides/3-(2-bromoacetyl)-2H-chromen-2-one and thiourea/phenylthiourea/selenourea in aqueous methanol at ambient temperature. Analytically pure products are formed within 1-3 min in excellent yields.