Synthesis of fused thiazolo[3,2-a]pyrimidinones: N-aryl-2-chloroacetamides as doubly electrophilic building blocks

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• 作者：Banothu Janardhan ; Basavoju Srinivas ; Bavantula Rajitha ; Crooks Peter A.
• 关键词：Thiazolo[3 ; 2-a]pyrimidinones ; 2-Chloro-N-phenylacetamide ; N-(Benzo[d]thiazol-2-yl)-2-chloroacetamide ; Single crystal X-ray analysis
• 刊名：Tetrahedron Letters
• 出版年：1 January, 2014
• 年：2014
• 卷：55
• 期：1
• 页码：224-226
• 全文大小：523 K

文摘

2-Chloro-N-phenylacetamide and N-(benzo[d]thiazol-2-yl)-2-chloroacetamide are doubly electrophilic building blocks for the formation of ring annulated thiazolo[3,2-a]pyrimidinone products. This synthetic route involves formation of the title compound in acceptable product yields by the elimination of the by-product, aniline/2-aminobenzothiazole. Analytical and spectral studies, as well as single crystal X-ray data on the representative compound ass="boldFont">6c confirmed the structure of all the reaction products.