Waist Circumference Provides an Indication of Numerous Cardiometabolic Risk Factors in Adults With Cerebral Palsy

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• 作者：Jennifer M. Ryan ; PhD^a ; ^{Jennifer.Ryan@brunel.ac.uk" class="auth_mail" title="E-mail the corresponding author} ; Vivion E. Crowley ; MRCPath ; FFPath (RCPI)^b ; Owen Hensey ; FRCPI^c ; Ailish McGahey ; BSc^c ; John Gormley ; PhD^a
• 关键词：Body mass index ; Cardiovascular diseases ; Cerebral palsy ; Metabolic syndrome X ; Rehabilitation ; Risk factors ; Waist circumference
• 刊名：Archives of Physical Medicine and Rehabilitation
• 出版年：2014
• 出版时间：August 2014
• 年：2014
• 卷：95
• 期：8
• 页码：1540-1546
• 全文大小：246 K

文摘

To report the prevalence of cardiometabolic risk factors in a cohort of adults with cerebral palsy (CP) and to investigate the ability of anthropometric measures to predict these factors.

Design

Cross-sectional study.

Setting

Testing took place in a laboratory setting.

Participants

Adults with CP (N=55; mean age, 37.5±13.3y; Gross Motor Function Classification System levels, I–V) participated in this study.

Interventions

Not applicable.

Main Outcome Measures

Total cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, triglycerides, glucose, insulin, and C-reactive protein levels were measured from a fasting venous blood sample. Insulin resistance was calculated using the Homeostasis Model Assessment (HOMA-IR) index. Blood pressure, body mass index (BMI), waist circumference (WC), waist-hip ratio, and waist-height ratio were also measured. The metabolic syndrome (MetS) was defined according to the 2009 Joint Interim Statement.

Results

The prevalence of the MetS was 20.5% in ambulatory adults and 28.6% in nonambulatory adults. BMI was associated with HOMA-IR only (β=.451; P<.01). WC was associated with HOMA-IR (β=.480; P<.01), triglycerides (β=.450; P<.01), and systolic blood pressure (β=.352; P<.05). Receiver operating characteristic curve analysis revealed that WC provided the best indication of hypertensive blood pressure, dyslipidemia, HOMA-IR, and the presence of multiple risk factors (area under the curve, .713–.763).

Conclusions

A high prevalence of the MetS was observed in this relatively young sample of adults with CP. WC was a better indicator of a number of risk factors than was BMI and presents as a clinically useful method of screening for cardiometabolic risk among adults with CP.