Computational fluid dynamics modeling of mixing effects for crystallization in coaxial nozzles
详细信息 查看全文
- 作者：Carl Pirkle Jr.a ; b ; Lucas C. Foguthb ; Steven J. Brenekc ; Kevin Girardc ; Richard D. Braatzb ; braatz@mit.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：Micromixers ; Static mixers ; Coaxial mixers ; Crystallization ; Computational fluid dynamics ; Population balance models
- 刊名：Chemical Engineering & Processing
- 出版年：2015
- 出版时间：November 2015
- 年：2015
- 卷：97
- 期：Complete
- 页码：213-232
- 全文大小：3649 K
文摘
- •
Cooling/antisolvent crystallization in coaxial mixers is modelled.
- •
Macro-mixing is modelled using computational fluid dynamics (CFD).
- •
The population balance equation is discretized and coupled to the CFD code.
- •
Micromixing within each CFD cell is simulated using a 3-environment model.
- •
The proposed computational algorithm is applied to crystallization of lovastatin.