Neurons and astroglia govern microglial endotoxin tolerance through macrophage colony-stimulating factor receptor-mediated ERK1/2 signals
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- 作者：Chun-Hsien Chua ; b ; Shijun Wanga ; Chia-Ling Lic ; Shih-Heng Chena ; Chih-Fen Hua ; d ; Yi-Lun Chunge ; Shiou-Lan Chenf ; Qingshan Wanga ; Ru-Band Luc ; g ; h ; i ; Hui-Ming Gaoj ; k ; l ; gaohm@nju.edu.cn" class="auth_mail" title="E-mail the corresponding author ; gao2@niehs.nih.gov" class="auth_mail" title="E-mail the corresponding author ; Jau-Shyong Honga
- 关键词：Microglia ; Endotoxin tolerance ; Neurons ; Astroglia ; M-CSF ; CSF1R ; ERK1/2 ; M2-like microglia ; Neuroprotection
- 刊名：Brain, Behavior, and Immunity
- 出版年：2016
- 出版时间：July 2016
- 年：2016
- 卷：55
- 期：Complete
- 页码：260-272
- 全文大小：2530 K
文摘
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Neurons and astroglia are required for microglial endotoxin tolerance.
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M-CSF secreted by neurons and astroglia modulates microglial endotoxin tolerance.
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CSF1R and ERK1/2 activation regulates microglial endotoxin tolerance.
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Tolerant microglia appear M2-like polarized phenotype.
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Tolerant microglia are neuroprotective.