Dynamic microglial modulation of spatial learning and social behavior
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- 作者：Luisa Torresa ; b ; Joan Danverc ; 1 ; Kyungmin Jib ; 1 ; Jeremy T. Miyauchib ; Danling Chenb ; Maria E. Andersond ; Brian L. Weste ; John K. Robinsond ; Stella E. Tsirkaa ; b ; styliani-anna.tsirka@stonybrook.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：Microglia depletion ; Hippocampus ; Memory ; Clodronate ; Csf1 inhibition
- 刊名：Brain, Behavior, and Immunity
- 出版年：2016
- 出版时间：July 2016
- 年：2016
- 卷：55
- 期：Complete
- 页码：6-16
- 全文大小：3575 K
文摘
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Local hippocampal microglial depletion alters learning and social behavior.
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Systemic microglia depletion alters learning but not social behavior.
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These behavioral changes are reversed upon microglial repopulation.