Pd(II)-catalyzed cascade Heck/intramolecular C(sp2)-H amidation reaction: An efficient route to 4-aryl-2-quinolinones
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- 作者：Chengqian Xiao ; Ziyi Wang ; Min Lei ; mlei@simm.ac.cn ; Lihong Hu ; lhhu@simm.ac.cn
- 关键词：4-Aryl-2-quinolinone ; C(sp2)&ndash ; H activation ; Intramolecular amidation ; Directing group ; Cascade reaction
- 刊名：Tetrahedron
- 出版年：2017
- 出版时间：12 January 2017
- 年：2017
- 卷：73
- 期：2
- 页码：204-211
- 全文大小：624 K
- 卷排序：73
文摘
A Pd(II)-catalyzed cascade Heck/intramolecular C(sp2)–H amidation reaction is described for the synthesis of 4-aryl-2-quinolinone derivatives. Substituted cinnamamide containing 2-(pyridin-2-yl)ethanamine unit reacts with aryl iodide to form intermediate by Heck reaction. Then, the intermediate takes place intramolecular amidation via C(sp2)–H activated process promoted by orientation group.