Emerging Mechanisms in Initiating and Terminating Autophagy

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• 作者：Manuela Antonioli¹ ; ² ; Martina Di Rienzo¹ ; ³ ; Mauro Piacentini¹ ; ³ ; Gian Maria Fimia¹ ; ⁴ ; ^{gianmaria.fimia@inmi.it}
• 关键词：ULK1 ; BECLIN-1 ; AMBRA1 ; TRAF6 ; TRIM ; CULLIN ; Exocyst ; IRGM.
• 刊名：Trends in Biochemical Sciences
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：42
• 期：1
• 页码：28-41
• 全文大小：2594 K
• 卷排序：42

文摘

Autophagy is a major degradative process activated in a rapid and transient manner to cope with stress conditions. Whether autophagy is beneficial or detrimental depends upon the rate of induction and the appropriateness of the duration. Alterations in both autophagy initiation and termination predispose the cell to death, and affect the execution of other inducible processes such as inflammation. In this review we discuss how stress signaling pathways dynamically control the activity of the autophagy machinery by mediating post-translational modifications and regulatory protein interactions. In particular, we highlight the emerging role of TRIM and CULLIN families of ubiquitin ligases which play opposite roles in the autophagy response by promoting or inhibiting, respectively, the activity of the autophagy initiation complex.