mTORC1 Coordinates Protein Synthesis and Immunoproteasome Formation via PRAS40 to Prevent Accumulation of Protein Stress

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• 作者：Young Sung Yun¹ ; Kwan Hyun Kim¹ ; Barbara Tschida² ; Zohar Sachs³ ; ⁴ ; Klara E. Noble-Orcutt³ ; Branden S. Moriarity⁴ ; ⁵ ; Teng Ai⁶ ; Rui Ding⁶ ; Jessica Williams⁶ ; Liqiang Chen⁶ ; David Largaespada² ; ⁴ ; ⁵ ; Do-Hyung Kim¹ ; ⁴ ; ^{dhkim@umn.edu" class="auth_mail" title="E-mail the corresponding author}
• 刊名：Molecular Cell
• 出版年：2016
• 出版时间：18 February 2016
• 年：2016
• 卷：61
• 期：4
• 页码：625-639
• 全文大小：4670 K

文摘

<dl class="listitem" id="list_ulist0010"><dt class="label">•dt><dd>

d="p0010">mTORC1 binds to immunoproteasome β subunit precursors via PRAS40

dd><dt class="label">•dt><dd>

d="p0015">mTORC1 promotes immunoproteasome formation via PRAS40 phosphorylation

dd><dt class="label">•dt><dd>

d="p0020">Immunoproteasomes are important for viability of mTORC1-hyperactive cells

dd><dt class="label">•dt><dd>

d="p0025">The mTORC1-immunoproteasome pathway is important for cell survival against stress

dd>dl>