• 作者：Mikael Ebbo^a ; ^b ; ^c ; ^d ; Laurence Gé ; rard^e ; ^f ; Sabrina Carpentier^g ; Fré ; dé ; ric Vé ; ly^a ; ^b ; ^c ; ^h ; Sophie Cypowyj^a ; ^b ; ^c ; Catherine Farnarier^h ; Nicolas Vinceⁱ ; Marion Malphettes^e ; ⁱ ; Claire Fieschi^e ; ⁱ ; Eric Oksenhendler^e ; Nicolas Schleinitz^a ; ^b ; ^c ; ^d ; Eric Vivier^a ; ^b ; ^c ; ^g ; ^{vivier@ciml.univ-mrs.fr" class="auth_mail" title="E-mail the corresponding author} ; for the DEFI Study Group¹
• 关键词：Natural Killer cells (NK cells) ; Innate immunity ; Common variable immunodeficiency (CVID) ; Redundancy of immune system ; Granuloma ; Invasive bacterial infections
• 刊名：EBioMedicine
• 出版年：2016
• 出版时间：April 2016
• 年：2016
• 卷：6
• 期：Complete
• 页码：222-230
• 全文大小：646 K

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CVID patients with low NK cell counts present increased rates of severe bacterial infections and granuloma.

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Mortality appears to be especially high in CVID patients with both severe CD4⁺ T cell and NK cell deficiency.

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NK cells could have non-redundant immune functions in patients with non-optimal adaptive immune response.

Forty years after their discovery, the functions of Natural Killer (NK) cells in natura remain poorly understood. Association studies linking clinical symptoms and defects in NK cell numbers or function are exceptional and poorly described in large cohorts of human patients. Our study analyzes the correlation between NK cell lymphopenia and clinical events in a large cohort of immunocompromised patients. We report the unexpected findings that severe invasive bacterial infections, especially bacteremia episodes, and non-infectious complications, especially granulomatous complications, are more frequent in common variable immunodeficiency patients with severe NK cell deficiency. These findings in natura highlights that NK cells may play a pivotal role in immunity in immunocompromised individuals, when the adaptive immune system is not optimal.