Spinal WNT pathway contributes to remifentanil induced hyperalgesia through regulating fractalkine and CX3CR1 in rats
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- 作者：Gu Gong ; Ling Hu ; Fuen Qin ; Liang Yin ; Xiaobo Yi ; Libang Yuan ; Wei Wu ; wuweichengdu2016@163.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：CX3CL1 ; chemokine (CX3C motif) ligand 1 ; FZ ; frizzled ; GAPDH ; glyceraldehydes 3-phosphate dehydrogenase ; i.t. ; intrathecally ; i.v. ; intravenously ; NMDA ; N-methyl-d-aspartate ; NS ; normal saline ; PWL ; paw withdrawal thermal latency ; PWT ; Paw withdrawal mechanical threshold ; OIH ; opioid-induced hyperalgesia ; SD ; standard deviation ; TSS ; titanic stimulation of the sciatic nerve
- 刊名：Neuroscience Letters
- 出版年：2016
- 出版时间：28 October 2016
- 年：2016
- 卷：633
- 期：Complete
- 页码：21-27
- 全文大小：1785 K
文摘
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Remifentanil anesthesia could elicit postoperative mechanical and thermal hyperalgesia.
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Up-regulation of WNT3a, FZ8 and β-catenin in spinal dorsal horn in remifentanil-induced postoperative hyperalgesia.
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Changes of spinal fractalkine and CX3CR1 expression in remifentanil-induced postoperative hyperalgesia.
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Intrathecal delivery of Fz-8/Fc and anti-CX3CR1 could attenuate remifentanil-induced postoperative hyperalgesia.
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WNT inhibition could reduce spinal fractalkine and CX3CR1 expression in remifentanil-induced postoperative hyperalgesia.