Development of cyanopyridine-triazine hybrids as lead multitarget anti-Alzheimer agents
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- 作者：Mudasir Maqboola ; Apra Manralb ; Ehtesham Jameelc ; Jitendra Kumara ; Vikas Sainib ; Ashutosh Shandilyad ; Manisha Tiwarib ; mtiwari07@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Nasimul Hodaa ; nhoda@jmi.ac.in" class="auth_mail" title="E-mail the corresponding author ; B. Jayaramd ; e ; f
- 关键词：DOHQPHWDPCNACE-UHFFFAOYSA-N
- 刊名：Bioorganic & Medicinal Chemistry
- 出版年：2016
- 出版时间：15 June 2016
- 年：2016
- 卷：24
- 期：12
- 页码：2777-2788
- 全文大小：2567 K
文摘
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A series of new cyanopyridine–triazine hybrids were developed as persuasive multifunctional anti-AD agents.
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Docking studies were performed on reported crystal structures of human acetylcholinesterase and butyrylcholinesterase.
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In vitro inhibitory potencies against acetylcholinesterase, and butyrylcholinesterase were assessed.
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20">Aβ1–42 disaggregation, oxygen radical absorbance, cytotoxicity, neuroprotection tests were also performed.