Design and synthesis of novel 2-substituted 11-keto-boswellic acid heterocyclic derivatives as anti-prostate cancer agents with Pin1 inhibition ability

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• 作者：Kun Li^a ; Lei Li^b ; Shuxiang Wang^a ; Xiaojing Li^a ; Tianyi Ma^a ; Dan Liu^a ; ^{sammyld@163.com} ; Yongkui Jing^b ; ^{yongkjing@yahoo.com} ; Linxiang Zhao^a ; ^{linxiang.zhao@vip.sina.com}
• 关键词：Acetyl-11-keto-β-boswellic acid ; Anti-proliferative activity ; Cyclin D1 ; Cell cycle ; Pin1
• 刊名：European Journal of Medicinal Chemistry
• 出版年：2017
• 出版时间：27 January 2017
• 年：2017
• 卷：126
• 期：Complete
• 页码：910-919
• 全文大小：1117 K
• 卷排序：126

文摘

Novel AKBA derivatives were synthesized as anti-prostate cancer agents. These compounds showed improved anti-proliferative activity over AKBA. 8f caused cell cycle arrest in G2/M and induced apoptosis. 8f decreased the levels of anti-apoptosis and cell cycle regulating protein. These compounds represented a novel class of Pin1 inhibitors.