Design and synthesis of novel 2-substituted 11-keto-boswellic acid heterocyclic derivatives as anti-prostate cancer agents with Pin1 inhibition ability
Novel AKBA derivatives were synthesized as anti-prostate cancer agents. These compounds showed improved anti-proliferative activity over AKBA. 8f caused cell cycle arrest in G2/M and induced apoptosis. 8f decreased the levels of anti-apoptosis and cell cycle regulating protein. These compounds represented a novel class of Pin1 inhibitors.