Regulation of cyclin D1 by arsenic and microRNA inhibits adipogenesis

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• 作者：Kevin Beezhold^a ; ^b ; Linda R. Klei^b ; Aaron Barchowsky^a ; ^{aab20@pitt.edu}
• 关键词：Arsenic ; microRNA ; Cyclin D1 ; HuR ; Adipogenesis ; Mesenchymal stem cell
• 刊名：Toxicology Letters
• 出版年：2017
• 出版时间：4 January 2017
• 年：2017
• 卷：265
• 期：Complete
• 页码：147-155
• 全文大小：1312 K
• 卷排序：265

文摘

Arsenic promotes metabolic disease through poorly understood mechanisms involving pathogenic remodeling of metabolic tissue. Low level arsenic exposure induced expression of miR-29b to impair human mesenchymal stem cell adipogenic differentiation. miR-29a disrupted adipogenesis involved sustained cyclin D expression that prevented cell cycle exit for differentiation. The work elucidated a novel mechanism for disruption of adipose metabolic homeostasis following arsenic exposure.ollowing arsenic exposure.