Rebamipide induces the gastric mucosal protective factor, cyclooxygenase-2, via activation of 5′-AMP-activated protein kinase

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• 作者：Sunyoung Lee ; Seongkeun Jeong ; Wooseong Kim ; Dohoon Kim ; Yejin Yang ; Jeong-Hyun Yoon ; Byung Joo Kim¹ ; Do Sik Min ; ^{minds@pusan.ac.kr} ; Yunjin Jung ; ^{jungy@pusan.ac.kr}
• 关键词：Rebamipide ; AMP-activated protein kinase ; Cyclooxygenase-2 ; Gastric ulcer
• 刊名：Biochemical and Biophysical Research Communications
• 出版年：2017
• 出版时间：29 January 2017
• 年：2017
• 卷：483
• 期：1
• 页码：449-455
• 全文大小：883 K
• 卷排序：483

文摘

Rebamipide activates AMPK, leading to COX-2 induction in gastric cancer cells Inhibition of AMPK attenuates the anti-gastric ulcer effects of rebamipide. Rebamipide increases gastric COX-2 and PGE2 level via AMPK activation.