Modes of remodeling in the cortical cytoskeleton of vascular endothelial cells

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• 作者：Pesen ; Devrim ; Hoh ; Jan H.
• 关键词：Endothelial cell ; Cytoskeletal dynamics ; Atomic force microscopy ; Mechanotransduction
• 刊名：FEBS Letters
• 出版年：2005
• 出版时间：January 17, 2005
• 年：2005
• 卷：579
• 期：2
• 页码：473-476
• 全文大小：262 K

文摘

The cortical cytoskeleton of vascular endothelial cells plays an important role in responding to mechanical stimuli and controlling the distribution of cell surface proteins. Here, we have used atomic force microscopy to visualize the dynamics of cortical cytoskeleton in living bovine pulmonary artery endothelial cells. We demonstrate that the cortical cytoskeleton, organized as a complex polygonal mesh, is highly dynamic and shows two modes of remodeling: intact-boundary-mode where mesh element boundaries remain intact but move at aaa0.08aam/min allowing the mesh element to change shape, and altered-boundary-mode where new mesh boundaries form and existing ones disappear.