Inverse relationship between elemental selenium nanoparticle size and inhibition of cancer cell growth in vitro and in vivo
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- 作者：Yijun Wang1 ; Pingping Chen1 ; Guangshan Zhao ; Kang Sun ; Daxiang Li ; Xiaochun Wan ; Jinsong Zhang ; zjs@ahau.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：Selenium ; Nanoparticles ; Size ; Cytotoxicity ; Reactive oxygen species
- 刊名：Food and Chemical Toxicology
- 出版年：2015
- 出版时间：November 2015
- 年：2015
- 卷：85
- 期：Complete
- 页码：71-77
- 全文大小：915 K
文摘
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SeNPs size-dependently inhibited cancer cell proliferation in vitro and in vivo.
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The inhibitory activity was inversely related to SeNP size.
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Concentration dependent GSH-mediated production of ROS may be the mediator of cytotoxicity.