Evaluation of in vitro and in vivo safety profile of the Indian traditional medicinal plant Grewia tiliaefolia
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- 作者：Sheeja Malar Dicsona ; Muniasamy Samuthirapandib ; Archunan Govindarajub ; Pandima Devi Kasia ; devikasi@yahoo.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Cytotoxicity ; PBMC ; Genotoxicity ; Salmonella typhimurium ; Mutagenicity ; Histopathology ; Ames assay ; Toxicology ; Haematology ; Wistar rats
- 刊名：Regulatory Toxicology and Pharmacology
- 出版年：2015
- 出版时间：October 2015
- 年：2015
- 卷：73
- 期：1
- 页码：241-247
- 全文大小：1296 K
文摘
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Safety profile of methanolic extract of Grewia tiliaefolia studied.
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No cytotoxicity in Peripheral blood mononuclear cells found up to 2000 μg/ml.
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No evidence of genotoxicity and mutagenicity was found for tested concentrations.
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In vivo toxicity studies showed no death or potent toxicity to any organ system.
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A NOAEL of 2000 mg/kg b.w was proposed in Wistar rats.