Structure-anticonvulsant activity studies in the group of (E)-N-cinnamoyl aminoalkanols derivatives monosubstituted in phenyl ring with 4-Cl, 4-CH3 or 2-CH3
(E)-N-cinnamoyl derivatives of aminoalkanols were tested in rodents. Maximal electroshock, subcutaneous pentylenetetrazole and 6-Hz tests were performed. Anticonvulsant activity was enhanced by p-Cl and o-CH3 substitution in phenyl ring. Benzodiazepine receptors and serotonergic receptors were possible molecular targets. Tested compounds were stable in rat liver microsomes model of biotransformation.