Central obesity is associated with non-cirrhotic portal vein thrombosis

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• 作者：Christophe Bureau¹ ; ^&dagger ; ; ^{bureau.c@chu-toulouse.fr" class="auth_mail" title="E-mail the corresponding author} ; Julie Laurent¹ ; ^&dagger ; ; Marie Angè ; le Robic¹ ; Camille Christol¹ ; Maeva Guillaume¹ ; Jean Bernard Ruidavets² ; Jean Ferrieres³ ; Jean Marie Pé ; ron¹ ; Jean Pierre Vinel¹
• 关键词：PVT ; portal vein thombosis ; SPVT ; secondary portal vein thrombosis group ; IPVT ; idiopathic portal vein thrombosis group ; C-SPVT ; control group for secondary portal vein thrombosis group ; C-IPVT ; control group for idiopathic portal vein thrombosis ; VTE ; venous thromboembolism ; MetS ; Metabolic syndrome ; BMI ; body mass index ; INR ; international normalized ratio ; ALT ; alanine aminotransferase ; AST ; aspartate aminotransferase ; HDL ; high-density lipids ; γGT ; Gamma glutamyl transpeptidase ; CRP ; C-react
• 刊名：Journal of Hepatology
• 出版年：2016
• 出版时间：February 2016
• 年：2016
• 卷：64
• 期：2
• 页码：427-432
• 全文大小：696 K

文摘

30–40% of portal vein thrombosis (PVT) remains of unknown origin. An association between metabolic syndrome (MetS) and peripheral vein thrombosis has been reported but not with PVT, to date. The aim of this study was to investigate the association between MetS and PVT.

Methods

Between 2003 and 2014, all consecutive patients with non-cirrhotic PVT were prospectively included. Patient’s characteristics and risks factors were recorded at the time of inclusion. Controls were selected by random in the general population and were matched 1/1 according to age and sex.

Results

Seventy-nine patients with PVT were included: 40 present with at least one risk factor for PVT (SPVT) and 39 were found to be idiopathic (IPVT). The prevalence of MetS was 25.6% in SPVT group vs. 47.4% in IPVT group and 17.9% in controls from the general population (C-IPVT: p = 0.01). The waist circumference and body mass index were higher in the IPVT group than in the SPVT group (105 vs. 93 cm, p = 0.004 and 29.4 vs. 25.0 kg/m², p = 0.004) and in the C-IPVT group (105 vs. 92 cm, p = 0.001 and 29.4 vs. 25.8 kg/m², p = 0.003). Overweight was observed in 82.0% of patients in the IPVT group vs. 44% in the SPVT group (p = 0.002) and 51% in the C-IPVT group (p = 0.01). The mean visceral fat area was higher in IPVT than in SPVT (18,223 mm²vs. 12,690 mm², p = 0.02). In multivariate analyses, an increase in waist circumference was the strongest parameter associated with idiopathic PVT.

Conclusion

Central obesity is associated with PVT and could become one of the main risk factors for digestive thromboses.