Mild forced treadmill exercise enhances spatial learning in the aged rat
详细信息 查看全文
- 作者：David S. Albeck ; Kazuhiro Sano ; Gayle E. Prewitt and Lori Dalton
- 关键词：Alzheimer's disease ; Basal forebrain ; Morris water maze ; NGF ; BDNF ; Neutrophin
- 刊名：Behavioural Brain Research
- 出版年：2006
- 出版时间：3 April 2006
- 年：2006
- 卷：168
- 期：2
- 页码：345-348
- 全文大小：117 K
文摘
This study addresses whether or not mild, forced treadmill exercise improves learning and increases neurotrophin levels in the basal forebrain (BF). Neurotrophin deficits in the BF have been implicated in Alzheimer's disease, and physical exercise increases neurotrophins. Aged rats exercised for 7 weeks found the hidden platform faster than controls (F(1, 10) = 14.6, p < 0.05), and swam shorter pathlengths (F(1, 10) = 12.6, p < 0.05), with no difference in swim speed. Neurotrophins did not differ.