Ultrasound Stimulation of Different Dental Stem Cell Populations: Role of Mitogen-activated Protein Kinase Signaling
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- 作者：Qianhua Gao ; MS ; A. Damien Walmsley ; PhD ; Paul R. Cooper ; PhD ; Ben A. Scheven ; PhD ; b.a.scheven@bham.ac.uk" class="auth_mail" title="E-mail the corresponding author
- 关键词：Bone marrow mesenchymal stem cells ; cell proliferation ; dental pulp stem cells ; dental tissue regeneration ; low-intensity pulsed ultrasound ; mitogen-activated protein kinase signaling ; mesenchymal stem cells ; periodontal ligament&ndash ; derived stem cells ; ultrasound
- 刊名：Journal of Endodontics
- 出版年：2016
- 出版时间：March 2016
- 年：2016
- 卷：42
- 期：3
- 页码：425-431
- 全文大小：2371 K
文摘
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Three dental-related mesenchymal stem cell (MSC) cultures were established and compared: dental pulp stem cells (DPSCs), bone marrow stem cells (BMSCs), and periodontal ligament–derived stem cells.
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Low-intensity pulsed ultrasound (LIPUS) stimulated MSC proliferation. DPSCs, BMSCs, and PDLSCs responded to LIPUS in an intensity-dependent manner.
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Distinct mitogen-activated protein kinases were involved in the response to LIPUS of the 3 MSC types.
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LIPUS may be considered as a therapeutic tool for dental repair.