A vaccine composed of a hypothetical protein and the eukaryotic initiation factor 5a from Leishmania braziliensis cross-protection against Leishmania amazonensis infection

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• 作者：Mariana Costa Duarte^a ; ^b ; Daniela Pagliara Lage^b ; Ví ; vian Tamietti Martins^b ; Lourena Emanuele Costa^b ; Ana Maria Ravena Severino Carvalho^a ; Fernanda Ludolf^b ; Thaí ; s Teodoro de Oliveira Santos^b ; Danniele Luciana Vale^a ; Bruno Mendes Roatt^a ; Daniel Menezes-Souza^a ; ^b ; Ana Paula Fernandes^c ; Carlos Alberto Pereira Tavares^d ; Dr. Eduardo Antonio Ferraz Coelho^a ; ^b ; ^{eduardoferrazcoelho@yahoo.com.br} (Prof.)
• 关键词：Hypothetical proteins ; Eukaryotic initiation factor 5a ; Cross-protection ; Vaccine ; Tegumentary leishmaniasis ; Th1 immunity
• 刊名：Immunobiology
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：222
• 期：2
• 页码：251-260
• 全文大小：1934 K
• 卷排序：222

文摘

Two antigenic L. braziliensis proteins were identified. They present high amino acids homology between different Leishmania species. A polyproteins vaccine was based on these two recombinant proteins. Mice were immunized and challenged with L. amazonensis promastigotes. Protection was correlated with low parasite load and a parasite-specific Th1 response.