Model calculations of radiation induced damage in 1-methylthymine:9-methyladenine

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• 作者：Chen ; Yuhua ; Close ; David
• 关键词：Radiation damage to DNA ; DNA bases ; Model calculations ; Methyladenine and methylthymine
• 刊名：Journal of Molecular Structure: THEOCHEM
• 出版年：2001
• 出版时间：August 6, 2001
• 年：2001
• 卷：549
• 期：1-2
• 页码：55-61
• 全文大小：192 K

文摘

Detailed electron paramagnetic resonance and electron nuclear double resonance experiments on the co-crystalline complex of 1-methylthymine:9-methyladenine (MTMA) have revealed that the major radiation induced products at low temperatures (10K) are MTMA1, a radical formed by net hydrogen abstraction from the C5 methyl group on thymine, and MTMA2, a radical formed by net hydrogen abstraction of the N1 methyl group on thymine. The following four minor products were also observed: MTMA3, the C4–OH protonated anion of thymine, MTMA4, the C6 H-addition product of thymine, and MTMA5 and MTMA6, radicals formed by net H-addition to C2 and C8 of the adenine base.