Aromatic amines from polyurethane adhesives in food packaging: The challenge of identification and pattern recognition using Quadrupole-Time of Flight-Mass Spectrometry^E

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• 作者：Davinson Pezo^a ; Mauro Fedeli^b ; Osvaldo Bosetti^b ; Cristina Ner&iacute ; n^a ; ^{cnerin@unizar.es}
• 关键词：Multilayer food packaging ; Migration ; Primary aromatic amines ; Non-intentionally added substances ; Polyurethane adhesives ; Solid phase extraction
• 刊名：Analytica Chimica Acta
• 出版年：2012
• 出版时间：5 December, 2012
• 年：2012
• 卷：756
• 期：Complete
• 页码：49-59
• 全文大小：808 K

文摘

Toxic primary aromatic amines (PAAs) are reaction products from residual isocyanates in polyurethane adhesives. The maximum migration level of the total sum of PAAs is 10 ng g^?1 of food. This paper reports on a method for quantification of 18 PAAs by UHPLC-MS/MS that was optimised and applied to a series of industrial laminates prepared from polyurethane adhesives. Non-intentionally added substances (NIAS), impurities and other migrants were identified by Q-TOF/MS^E. A comparison of the quantitative values obtained by the colorimetric method using NEDA and by UHPLC-MS/MS confirmed that the first method can overestimate the quantification of PAAs. This could be attributed to the impurities and other NIAS present in the plastic laminate. Values of R² in the analytical characteristics of UHPLC-MS/MS were obtained, the best value being 0.9964 and the most unfavourable 0.7626. The detection limit (LOD) and the quantification limit (LOQ) were 2 pg g^?1 and 7 pg g^?1, respectively. The stability of the PAAs over time in the acidic simulant in contact with the plastic laminate is also reported.