Promotion effects of Lewis acid/(CH3)4NI on [Co(CO)₄]¡¥-catalyzed C-N bond activation in the carbonylation of trimethylamine

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• 作者：Yizhu Lei^a ; Rui Zhang^a ; Wenjia Han^a ; Hui Mei^a ; Yanlong Gu^a ; Bo Xiao^b ; Guangxing Li^a ; ^{ligxabc@163.com}
• 关键词：Carbonylation ; [Co(CO)4]¡¥ catalyst ; Lewis acid ; C&ndash ; N bond activation ; Amide
• 刊名：Catalysis Communications
• 出版年：2013
• 出版时间：5 August, 2013
• 年：2013
• 卷：38
• 期：Complete
• 页码：45-49
• 全文大小：391 K

文摘

An effective synthesis of N,N-dimethylacetamide (DMAc) via NaCo(CO)₄-catalyzed carbonylation of trimethylamine is reported. Lewis acid (AlCl₃, FeCl₃, BiCl₃, InCl₃ etc.) and (CH₃)₄NI were used as promoters to activate the unreactive sp³ carbon-nitrogen (C-N) bond of trimethylamine and a significant increase in catalytic activity was observed. High selectivity (98 % ) and yield of DMAc (96 % ) were obtained under relatively mild reaction conditions. Based on the role of promoters and the products in the reaction, a plausible mechanism that contains two different ways of activating C-N bond was proposed.