Cu(I)/Ag(I)-mediated decarboxylative trifluoromethylation of arylpropiolic acids with Me₃SiCF₃ at room temperature

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• 作者：Lingling Yang ; Linlin Jiang ; Yaming Li ; ^{ymli@dlut.edu.cn" class="auth_mail" title="E-mail the corresponding author} ; Xinmei Fu ; Rong Zhang ; Kun Jin ; Chunying Duan
• 关键词：Trifluoromethylation ; Decarboxylative coupling reaction ; Arylpropiolic acids ; Trifluoromethylated acetylenes ; Cu(I)/Ag(I)-mediated
• 刊名：Tetrahedron
• 出版年：2016
• 出版时间：7 July 2016
• 年：2016
• 卷：72
• 期：27-28
• 页码：3858-3862
• 全文大小：453 K

文摘

A novel Cu(I)/Ag(I)-mediated decarboxylative trifluoromethylation of arylpropiolic acids with Me₃SiCF₃ has been developed for the construction of Csp-CF₃ bond under mild conditions. This method proceeds smoothly at room temperature and shows a widely functional compatibility, providing a series of corresponding trifluoromethylated acetylenyl-containing aromatics in good yields.