Multicenter study for the evaluation of the antibody response against salmonella typhi Vi vaccination (EMPATHY) for the diagnosis of Anti-polysaccharide antibody production deficiency in patients with primary immunodeficiency
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- 作者：S. Sá ; nchez-Ramó ; na ; ssramon@salud.madrid.org" class="auth_mail" title="E-mail the corresponding author ; J. de Graciab ; AM. Garcí ; a-Alonsoc ; J.J. Rodrí ; guez Molinaa ; J. Melerod ; A. de André ; se ; J.M. Garcí ; a Ruiz de Moralesf ; A. Ferreirag ; J.G. Ocejo-Vinyalsh ; J.J. Cidi ; J.M. Garcí ; a Martí ; nezj ; T. Lasherasb ; M.L. Vargasd ; J. Gil-Herreraa ; M.C. Garcí ; a Rodrí ; guezg ; J.L. Castañ ; erg ; L.I. Gonzá ; lez Granadok ; L.M. Allendel ; P. Soler-Palacinm ; L. Herrá ; iza ; M. Ló ; pez Hoyosh ; J.M. Belló ; nn ; G. Silvae ; D.M. Gurbindoo ; J. Carbonea ; C. Rodrí ; guez-Sá ; inza ; N. Matamorosp ; A.R. Parkerq ; E. Ferná ; ndez-Cruza ; EMPATHY group
- 关键词：Specific polysaccharide antibody response ; CVID ; Vi polysaccharide antigen ; Pneumococcal polysaccharide antigens ; Typhim Vi
- 刊名：Clinical Immunology
- 出版年：2016
- 出版时间：August 2016
- 年：2016
- 卷：169
- 期：Complete
- 页码：80-84
- 全文大小：364 K
文摘
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Our data demonstrate similar lack of anti-polysaccharide responses to both Typhim Vi and pneumococcal immunization in CVID patients.
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Anti-Typhim Vi responses showed higher power of discrimination between CVID patients and healthy controls.
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Antibody response to Typhim Vi can represent a complementary assay for the diagnosis of anti-polysaccharide antibody production deficiency.