Antigen-specific IgA titres after 23-valent pneumococcal vaccine indicate transient antibody deficiency disease in children

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• 作者：Willemijn J.M. Janssen^a ; Stefan Nierkens^b ; Elisabeth A. Sanders^a ; ^b ; Marianne Boes^a ; ¹ ; Joris M. van Montfrans^a ; ¹ ; ^{J.vanMontfrans@umcutrecht.nl" class="auth_mail" title="E-mail the corresponding author}
• 关键词：APAD ; anti-polysaccharide antibody deficiency ; AUC ; area under the curve ; CVID ; Common Variable Immunodeficiency Disorder ; PnPS ; pneumococcal polysaccharide ; SD ; standard deviation ; TAD ; transient antibody deficiency of childhood ; ROC ; receiver operating characteristic
• 刊名：Vaccine
• 出版年：2015
• 出版时间：17 November 2015
• 年：2015
• 卷：33
• 期：46
• 页码：6320-6326
• 全文大小：377 K

文摘

Paediatric patients with antibody deficiency may either be delayed in development of humoral immunity or may be persistently deficient in antibody production. To differentiate between these entities, we examined the 23-valent pneumococcal polysaccharide (PnPS) vaccine-induced IgM-, IgG- and IgA antibody responses in a cohort of 66 children with recurrent respiratory tract infections. Individual serum titres against 11 pneumococcal serotypes were measured by Luminex. The cohort contained 33 antibody deficiency patients, 17 transient antibody deficiency patients and 16 patients without antibody deficiency diagnosis (control group). Transient antibody deficiency patients produced consistently higher levels of PnPS-specific IgA responses than antibody deficiency patients. Decreased IgA responses to serotypes 1, 5, 7F and 18C were most discriminative to stratify transient antibody deficiency patients from antibody deficiency patients with persistent disease. We conclude that measuring PnPS-specific IgA responses may predict the disease course in young children diagnosed with antibody deficiency and suggest confirmation of these data in a prospective setting.